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Product Detail & Benefits


Glucosamine sulfate is classified as an amino sugar, a type of carbohydrate used for structural tissues instead of as an energy source. It is the basic building block/raw material in joint cartilage, ligaments, and tendons. Glucosamine sulfate plays a major role in the synthesis of collagen, cartilage, bone, skin, and various lubricating fluids in joints. Glucosamine sulfate helps promote elasticity of joint movement and also functions as a mild anti-inflammatory.

Chondroitin sulfate is a natural component of several tissues in the body. Like glucosamine, chondroitin sulfate is one of the important building blocks for the repair of damaged cartilage. One of chondroitin sulfate's important functions is its ability to block the activity of enzymes that break down cartilage. This helps reduce inflammation and protects cartilage from further damage. Chondroitin sulfate also promotes lubrication and cushioning in the joints.

Methylsulfonylmethane, better known as MSM, is a metabolite of dimethylsulfoxide (DMSO), a well-known solvent, which has been used topically as an analgesic and anti-inflammatory. MSM is an organic form of sulfur, which is necessary for proper synthesis and maintenance of tissues such as skin, hair, nails, tendons and cartilage. MSM has been reported to reduce arthritic joint pain, enhance wound healing, and reduce allergic symptoms.

Tissue Rejuvenator's Enzyme Blend of peptidase, bromelain, papain, amylase, lipase, cellulase, and phytase not only aids in the complete absorption of the nutrient components in the product, it provides its own potent anti-inflammatory benefits.

Boswellia serrata is an Ayurvedic herb that has been extensively used as an anti-inflammatory for the treatment of arthritis. Its primary active ingredients are triterpene acids, which may also be useful for treating exercise-induced asthma and irritable bowel syndrome.

Devil's Claw is a South African herb containing substances called iridoid glycosides that have anti-inflammatory properties. It is also purported to help relieve mild stomach upset.

Yucca Root is frequently used to combat osteoarthritis and rheumatoid arthritis symptoms. It contains high levels of beneficial phytochemical compounds known as saponins, which may provide anti-viral, anti-fungal, and antibacterial benefits as well.

Turmeric (Curcuma longa) contains a substance called curcumin, which has not only anti-inflammatory properties but also liver protecting, antibiotic, and antioxidant properties as well.

Quercetin is a water-soluble flavonoid typically found in onions, apples, leafy vegetables, and other food sources. It is both a potent antioxidant and anti-inflammatory and may also act as an antihistamine.

Undenatured Type II Collagen (UC-II™) is a patented, extensively studied dietary ingredient derived from chicken sternum cartilage. Through a complex process called oral tolerization, UC-II™ works with the immune system to promote healthy joints and increase joint mobility and flexibility.


Extra Benefits:
Tumeric, one of the components in Tissue Rejuvenator, in addition to being a powerful anti-inflammatory, is also a well-known antioxidant and anti-carcinogenic agent.

If you're injured and can't wait to get back into action, or if you're trying to prevent joint and tissue injuries, add Tissue Rejuvenator to your order list. It's a powerful, dual-purpose product, supplying your body with nutrients that provide the raw materials it needs to promote rapid tissue repair, while also helping to reduce inflammation, soreness, and pain-without requiring you to over-rely on NSAIDs (non-steroidal anti-inflammatory drug). Remember, as with all our products, Tissue Rejuvenator, the combined rebuild-relieve joint product, is fully guaranteed. If it doesn't work for you, you get a full refund. Period.

Nutrition Labels:

Tissue Rejuvenator
Supplement Facts
Serving Size 4 Capsules
Amount Per Serving % Daily Value*
Glucosamine Sulfate 500mg
Chondroitin Sulfate 500mg
MSM (Methylsulfonylmethane) 500mg
Enzyme Blend (peptidase and bromelain, papain, protease, amylase, lipase, cellulase, and phytase) 400mg
Boswellia Serrata 400mg
Devils Claw 200mg
Yucca Root 100mg
Turmeric (Curcuma longa) Root Extract 100mg
Quercetin (Saphora Japonica Source) 20mg
Undenatured Type II Collagen** 5mg
* The Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
† Daily Value not established.
**UC-II brand undenatured type II collagen (U.S. Patents 5,645.851, 5,637,321, 5,529,786, and 5,750,144). UC-II™ is a trademark of InterHealth N.I.
Other Ingredients: Stabilized Rice Bran, Vegetable Capsules (pullulan and water)

Nutrition & Usage Tips

Tissue Rejuvenator (AES vol 13.14)

Tissue Rejuvenator (AES vol 13.14)

Stay in the game . . . safely and naturally!

Tissue Rejuvenator's Glucosamine Sulfate & Chondroitin Sulfate

Tissue Rejuvenator's Glucosamine Sulfate & Chondroitin Sulfate

What do you say in response to the NEJM study on Glucosamine and Chondroitin. They found that it only beat the placebo for severe joint pain.

Tissue Rejuvenator

Tissue Rejuvenator

Maintain healthy joints safely and naturally

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Product Reviews

Rated 5 out of 5 by from A necessary item for everyone I once dislocated my shoulder and without this product even sleeping is hard. It takes a few weeks to build it up, but I have learned now, I won't go without. If you have any joint issues, take this product, give it a bottle. You won't regret.
Date published: 2014-06-25
Rated 5 out of 5 by from Helped my rheumatoid arthritis when nothing else did.
Date published: 2014-06-18
Rated 5 out of 5 by from Great Natural Alternative to Anti-Inflammatories I started using this after my hip surgery instead of ibuprofen because I hate taking drugs if I can help it - this was a great find. Helped keep my inflammation down without needing the ibuprofen. Also minimized post-workout soreness getting back into activity.
Date published: 2014-06-04
Rated 3 out of 5 by from Not sure yet about this product. Feeling no difference after about 3 weeks. Going to stick with it and really hope that it works!
Date published: 2014-06-04
Rated 5 out of 5 by from Fabulous product! I'm a distance runner and this is all I use to maintain. But when I'm injured and recovering I simply ramp up my dose and it speeds my recovery!
Date published: 2014-05-31
Rated 1 out of 5 by from No help at all I purchased this product in hopes of cutting down on some of the ibuprofen I take daily for soreness and injury's sustained in tennis. I would love to say the product work But could feel no relief of pain or soreness. Last night I Looked at the ingredients and found them to be most of the ones I have read have little or no affect... Like so Many supplements, I feel they are a waste of money.
Date published: 2014-05-28
Rated 5 out of 5 by from Helps my Achilles tendonosis I have used Tissue Rejuvenator during times when my Achilles flares up with tendonosis. Along with icing and stretching, this product does appear to speed up the healing process. I take several a day when my Achilles acts up.
Date published: 2014-05-20
Rated 5 out of 5 by from Recovery & Injury Prevention I added Tissue Rejuvenator to my daily supplements as I started to get some tendinitis on and off last season. Along with some strength training, I truly believe this supplement has helped aid my injuries and now ongoing maintenance/recovery. Now pushing 40 years old, I am pushing more watts and faster paces than ever.
Date published: 2014-05-20
Rated 5 out of 5 by from No pain during a marathon buildup I'm a 63 y/o runner. Last Summer, I did a 16-week marathon buildup, with two 20-mile runs. Taking Tissue Rejuvenator, I was pain-free. I'm a believer in the product.
Date published: 2014-05-11
Rated 5 out of 5 by from for my goal of a speedy recovery I'm using this to manage swelling in an acute injury as an adjunct along with NSAIDS and pain medicine as needed.
Date published: 2014-05-11
Rated 5 out of 5 by from Greatly reduces soreness I started taking Tissue Rejuvenator mid-way during my training for a half marathon. As the miles increased, I used to be sore in my legs after my runs and the soreness used to last over the weekend. Since I started taking TR, it really helped me fight the soreness and I was easily able to get the long miles on Saturday morning and be active rest of the week. I also feel it helps me with my weight training workouts and I will continue to take TR to fight soreness and be active.
Date published: 2014-05-07
Rated 5 out of 5 by from Good product I use this daily for maintenance/ injury prevention purposes, it seems to do the job.
Date published: 2014-05-05
Rated 5 out of 5 by from Helps with Joint Pain and Mobility I began using Tissue Rejuvenator at 4 capsules twice daily about 2 months ago to help with recovery from Plantar Faciitis. I believe it did help with that recovery along with other treatments including ice, stretching, massage, and physical therapy. I now take 2 capsules twice daily for maintenance along with a Hyaluronic Acid supplement and I have noticed a positive difference in joint motion with less pain. I am a 43 years old triathlete, so I can use all the joint lubrication I can get. I would recommend giving it a try if you have not tried joint supplements before or if others have failed.
Date published: 2014-05-01
Rated 4 out of 5 by from Helpful for every day Have been using this along with other modalities and find it a great Benefit for reducing inflammation
Date published: 2014-04-25
Rated 5 out of 5 by from It Works! I gave up my joint supplement and NSAID and started using Tissue Rejuvenator 10 days ago and so far Yoga and Cycling are pain free and I have better range of movement in my problem knee. Love it and can't believe I waited so long to try it!
Date published: 2014-04-23
Rated 5 out of 5 by from Holds me together! I've been using Tissue Rejuvenator for about 2 years now and it is a key component of my joint health. I "forget" how great it is until I run out and the aches and pains start in my knees! Note to self....don't run out!
Date published: 2014-04-22
Rated 5 out of 5 by from Love Tissue Rejuvenator I was out of this product for a while. Recently re-ordered it and my knee joints are already feeling better. Having my husband try it too.
Date published: 2014-04-22
Rated 5 out of 5 by from Great stuff As a runner I use this product every day to help keep me feeling good. I first used this product when I encountered a hamstring strain and it help heel and make my strain feel better faster than it would have with out. So with or without an injury I use this daily!
Date published: 2014-04-21
Rated 5 out of 5 by from Great product Have been ice/advil treatment plan for a while now, and figured I should try Tissue Rejuvenator. TR will now be my goto not advil, it really works that good.
Date published: 2014-04-19
Rated 5 out of 5 by from actually works! This did exactly what it claims! I was surprised how much better i felt after using it. im an ultra runner and i hate taking NSAIDS ever, so this is perfect for me. Ide been having annoying hip pain (piriformis issues) for a year, and this has completely fixed the muscle-swelling problem and so now i also do not have the sciatic nerve pain either that was a result of the piriformis swelling and pressing on it. Im thrilled with this and hope they never stop making it! :)
Date published: 2014-04-13
Rated 5 out of 5 by from Great product my neice gave me my first bottle Great product my neice gave me my first bottle. I have taken it the last six months after my first and second total knee replacement. I didn't really know how well they helped with healing, inflamation and pain until I ran out. I very soon realized that I needed to order more and take the recomended higher dosage for recovery. I highly recommend this product esspecially if you are in recovery mode.
Date published: 2014-04-08
Rated 5 out of 5 by from T/R for fast healing I took the recommended regimen ot Tissue Rejuvenator while recovering from rotator cuff surgery. My PT told me that, even at age 78, I am a fast healer. I attribute a great deal of that speed to T/R. Great stuff - I've ordered more and plan to take it regularly.
Date published: 2014-04-06
Rated 4 out of 5 by from Great for my knees and any other injury! I have been taking it for a couple of years.
Date published: 2014-03-31
Rated 5 out of 5 by from Must have - if you have joint pain! My husband has had pain in his knees for a number of years. I use hammer products with my running and saw the Tissue Rejuvenator and decided to purchase this for him. It has helped tremendously, he notices if he doesn't use the product - it's a keeper :)!
Date published: 2014-03-20
Rated 3 out of 5 by from Not sure how it helps. I am about 2/3 finished with my first bottle (120 pills). I cannot put my finger on it yet. I've been taking this every morning and evening but I am also taking Recoverite after every workout. I do feel great and soreness is not an issue anymore but I think it's not the TR but rather the Recoverite. Before taking any Hammer supplements I used to have an ugly pain in my both shoulder blades. Six weeks taking all these products, the pain somehow receded by a considerable amount, but did not disappear. I work out 5-6 days a week.
Date published: 2014-03-20
Rated 5 out of 5 by from Fantastic suppplement I have had the surgery to correct 2 herniated discs in my lower back and now I suffer from severe degenerated discs in those locations. I have been taking this for a few weeks, hoping to not have to take the anti-inflammatory meds any more. It is working. I am very happy with this product. It has greatly reduced my daily pain, and it has increased my mobility and I am able to function at a higher level. I would recommend this product to anyone who has joint problems
Date published: 2014-03-11
Rated 4 out of 5 by from Have been using this for awhile. Does help somewhat.
Date published: 2014-03-07
Rated 5 out of 5 by from Awesome Product I love this product, my knees love this product! My entire system functions with fewer aches and pains after a good workout.
Date published: 2014-03-02
Rated 5 out of 5 by from Best to be Pre-emptive This week I started strength conditioning with a coach and ordered TR because I knew I would be sore. On the 3rd day of training we did squats on a new machine I had never used before that worked ALL the muscles in my legs. I started TR that morning before doing the work and woke up the next day with no muscle soreness AT ALL. This surprised me greatly. Unfortunately, TR does not work for muscles that are already sore but that is to be expected. TR seems to be a great product if you stay one step ahead of muscle soreness. Use TR before the heavy days to prevent the pain. How I was not sore from the squats is amazing. It was my first day squatting with heavy weights in quite some time!! As a 44 year-old-athlete trying to stay on the podium in SUP races I need to train hard and stay pain free. TR and I are off to one heck of a great start in our long-term relationship!
Date published: 2014-02-27
Rated 5 out of 5 by from I noticed a difference in just a couple of days Both my knees have been bothering me this winter from running in preparation for a marathon next month. I've tried all the usual things like stretching, yoga, ice packs, and a supplement from the grocery store and none of them really made a difference. I felt a difference in just a couple of days with this product. I plan to stick to taking the supplement at least once a day until I feel recovered and may continue to take it as a preventative measure. I'm running the Big Three Marathons (London + Missoula + NYC) this year and want to enjoy every training run without the soreness.
Date published: 2014-02-27
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