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Product Detail & Benefits


Glucosamine sulfate is classified as an amino sugar, a type of carbohydrate used for structural tissues instead of as an energy source. It is the basic building block/raw material in joint cartilage, ligaments, and tendons. Glucosamine sulfate plays a major role in the synthesis of collagen, cartilage, bone, skin, and various lubricating fluids in joints. Glucosamine sulfate helps promote elasticity of joint movement and also functions as a mild anti-inflammatory.

Chondroitin sulfate is a natural component of several tissues in the body. Like glucosamine, chondroitin sulfate is one of the important building blocks for the repair of damaged cartilage. One of chondroitin sulfate's important functions is its ability to block the activity of enzymes that break down cartilage. This helps reduce inflammation and protects cartilage from further damage. Chondroitin sulfate also promotes lubrication and cushioning in the joints.

Methylsulfonylmethane, better known as MSM, is a metabolite of dimethylsulfoxide (DMSO), a well-known solvent, which has been used topically as an analgesic with anti-inflammatory properties. MSM is an organic form of sulfur, which is necessary for proper synthesis and maintenance of tissues such as skin, hair, nails, tendons and cartilage.

Tissue Rejuvenator's Enzyme Blend of peptidase, bromelain, papain, amylase, lipase, cellulase, and phytase not only aids in the complete absorption of the nutrient components in the product, it provides its own potent anti-inflammatory benefits.

Boswellia serrata is an Ayurvedic herb with anti-inflammatory properties. Its primary active ingredients are triterpene acids, which may also be useful for relief from exercise-induced breathing difficulties.

Devil's Claw is a South African herb containing substances called iridoid glycosides that have anti-inflammatory properties. It is also purported to temporary relief of mild stomach upset.

Yucca Root is frequently used to offer temporary relief from osteoarthritis and rheumatoid arthritis symptoms. It contains high levels of beneficial phytochemical compounds known as saponins, which may provide anti-fungal and antibacterial benefits as well.

Turmeric (Curcuma longa) contains a substance called curcumin, which has not only anti-inflammatory properties but also provides liver support and antioxidant properties as well.

Quercetin is a water-soluble flavonoid typically found in onions, apples, leafy vegetables, and other food sources. It has both antioxidant and anti-inflammatory properties.

Undenatured Type II Collagen (UC-II™) is a patented, extensively studied dietary ingredient derived from chicken sternum cartilage. Through a complex process called oral tolerization, UC-II™ works with the immune system to promote healthy joints and increase joint mobility and flexibility. (U.S. Patents 5,645.851, 5,637,321, 5,529,786, and 5,750,144). UC-II™ is a trademark of InterHealth N.I.


Extra Benefits:
Turmeric, one of the components in Tissue Rejuvenator, in addition to being a powerful anti-inflammatory, is also a well-known antioxidant and anti-carcinogenic agent.

If you're injured and can't wait to get back into action, or if you're trying to prevent joint and tissue injuries, add Tissue Rejuvenator to your order list. It's a powerful, dual-purpose product, supplying your body with nutrients that provide the raw materials it needs to promote rapid tissue repair, while also helping to reduce inflammation, soreness, and pain-without requiring you to over-rely on NSAIDs (non-steroidal anti-inflammatory drug). Remember, as with all our products, Tissue Rejuvenator, the combined rebuild-relieve joint product, is fully guaranteed. If it doesn't work for you, you get a full refund. Period.

Nutrition Labels:

Tissue Rejuvenator
Supplement Facts
Serving Size 4 Capsules
Amount Per Serving % Daily Value*
Glucosamine Sulfate 500mg
Chondroitin Sulfate 500mg
MSM (Methylsulfonylmethane) 500mg
Proprietary Enzyme Blend (peptidase, bromelain, papain, protease, amylase, lipase, cellulase, and phytase) 400mg
Boswellia Serrata 400mg
Devils Claw 200mg
Yucca Root 100mg
Turmeric (Curcuma longa) Root Extract 100mg
Quercetin (Saphora Japonica Source) 20mg
Undenatured Type II Collagen 5mg
* The Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
† Daily Value not established.
Other Ingredients: Stabilized Rice Bran, Vegetable Capsules (plant cellulose and water)

Fueling & Usage Tips

Tissue Rejuvenator: Promote repair safely and naturally!

Tissue Rejuvenator: Promote repair safely and naturally!

Tissue Rejuvenator has quickly become one of Hammer Nutrition's top-selling supplements, and with good reason - it works!

Tissue Rejuvenator's Glucosamine Sulfate & Chondroitin Sulfate

Tissue Rejuvenator's Glucosamine Sulfate & Chondroitin Sulfate

What do you say in response to the NEJM study on Glucosamine and Chondroitin. They found that it only beat the placebo for severe joint pain.

Tissue Rejuvenator

Tissue Rejuvenator

Maintain healthy joints safely and naturally

Tissue Rejuvenator - AES vol 13.14

Tissue Rejuvenator - AES vol 13.14

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Product Reviews

Rated 5 out of 5 by from Helps with Joint Pain and Mobility I began using Tissue Rejuvenator at 4 capsules twice daily about 2 months ago to help with recovery from Plantar Faciitis. I believe it did help with that recovery along with other treatments including ice, stretching, massage, and physical therapy. I now take 2 capsules twice daily for maintenance along with a Hyaluronic Acid supplement and I have noticed a positive difference in joint motion with less pain. I am a 43 years old triathlete, so I can use all the joint lubrication I can get. I would recommend giving it a try if you have not tried joint supplements before or if others have failed.
Date published: 2014-05-01
Rated 5 out of 5 by from I would write a jingle for this I love Tissue Rejuvenator! It is the best pain reliever I have ever used. I have recommended it to friends and family who are recovering from injuries and surgery and all of them have reported how much better they feel within such a short period of time!
Date published: 2016-05-23
Rated 5 out of 5 by from A must for high-volume training I recently purchased Tissue Rejuvenator after reading countless 5-star reviews for this product - they weren't lying, it really does work wonderfully. I consistently workout 6 days a week, four to five of the days being twice a day, with high-volume cycling and running. My feet and knees felt pressure and soreness - icing helped minimally but I was looking for something that could give me more relief without using pain killers (I'm not a fan of those) - since taking Tissue Rejuvenator, my heel and knee pain has been relieved ! When facing joint pain, I have taken this in the morning with breakfast and again with my post-workout Recoverite shakes along with Premium Insurance Caps. Works like a charm.
Date published: 2016-05-11
Rated 5 out of 5 by from Great product my neice gave me my first bottle Great product my neice gave me my first bottle. I have taken it the last six months after my first and second total knee replacement. I didn't really know how well they helped with healing, inflamation and pain until I ran out. I very soon realized that I needed to order more and take the recomended higher dosage for recovery. I highly recommend this product esspecially if you are in recovery mode.
Date published: 2014-04-08
Rated 3 out of 5 by from I tried this product as an alternative to Ibuprofin for reducing joint swelling and pain. I'm still on the fence about TR. The pills are large, so digestibility is not great. I would prefer smaller pills. I'm not sure I get the relief from swelling and pain management I was after. So far I'd rate this product just average.
Date published: 2014-01-27
Rated 5 out of 5 by from I noticed a difference in just a couple of days Both my knees have been bothering me this winter from running in preparation for a marathon next month. I've tried all the usual things like stretching, yoga, ice packs, and a supplement from the grocery store and none of them really made a difference. I felt a difference in just a couple of days with this product. I plan to stick to taking the supplement at least once a day until I feel recovered and may continue to take it as a preventative measure. I'm running the Big Three Marathons (London + Missoula + NYC) this year and want to enjoy every training run without the soreness.
Date published: 2014-02-27
Rated 5 out of 5 by from Relief from Nsaids Been using 2X daily Tissue Rejuvenator along with my daily essentials and still struggling to maintain activity level due to torn rotator cuff caused by downhill skiing accident this past February. Swimming has been difficult and with the help of Nsaids made it thru a descent triathalon race season. 2 wins, 3 3rd places in IM distance events. Although still unable to sleep on that side and limited mobility. A couple of weeks ago, I decided to double my intake of Tissue Rejuvenator and cut out the Nsaids. So far, it seems to be working. Although I have also been back in PT for the shoulder and swimming much less, I'm feeling like it's starting to improve with less inflammation and soreness and better sleep. Will continue to use 4X TR daily and hopefully get back to normal soon minus the Nsaids.
Date published: 2016-10-28
Rated 5 out of 5 by from Really delivers results This product deliver more than what I expected, It really helped me to regenerate old injured tissue, I even think it continues loosen up some of old injured, arthritic joints, ligaments , muscle fibers that were damage and became fibrous, I feel I have more flexibility recently and I also feel I recover quicker from long hard rides and work outs, I have offered to my wife and daughter; they are training for a half marathon soon, I observed they are recovering rather quick and their soreness lingers less than usual. I am not doing anything else to get this gains, go figure!
Date published: 2015-10-19
Rated 3 out of 5 by from tissue rejuvenator I have used these pills for over a month. I am not sure if it is given me all that I wanted. I have been taking Glucosamine Chondroitin & MSM for my joints for a long time and thought it might be better. To get the same quantities i would have to take 12 a day. I also don't seem to have all the relief I wanted.
Date published: 2014-10-27
Rated 5 out of 5 by from T/R for fast healing I took the recommended regimen ot Tissue Rejuvenator while recovering from rotator cuff surgery. My PT told me that, even at age 78, I am a fast healer. I attribute a great deal of that speed to T/R. Great stuff - I've ordered more and plan to take it regularly.
Date published: 2014-04-06
Rated 5 out of 5 by from Awesome product My friend gave me a sample of this when I severly strained my Achilles. My recover time was so much faster than usual. I take this product on a regular basis to help with my fybro myalgia. It seems to work better than any drugs I have been prescribed by any dr.
Date published: 2016-06-13
Rated 5 out of 5 by from Awesome product I started taking this product as soon as I received the bottle. I've been trying different products with the same ingredients...but, had to take three different ones in order to get what is in this ONE product. I have finally found "my" fountain of youth.
Date published: 2015-09-03
Rated 5 out of 5 by from Must have - if you have joint pain! My husband has had pain in his knees for a number of years. I use hammer products with my running and saw the Tissue Rejuvenator and decided to purchase this for him. It has helped tremendously, he notices if he doesn't use the product - it's a keeper :)!
Date published: 2014-03-20
Rated 5 out of 5 by from Tissue Rejuvenator is amazing I discovered Tissue Rejuvenator after a nagging hip injury turned out to be a chronic condition. I take it daily to combat the discomfort and inflammation. It has taken the place of NSAIDs in my household, I highly recommend Tissue Rejuvenator!!
Date published: 2016-08-06
Rated 5 out of 5 by from Surprised! Bought the Tissue Rejuvenator on the advice of my son. He is a long distance endurance bike racer and will compete in the SO. Cal. Stagecoach-400 later this March 2015. I had moderate pain after arthroscopis surgery on both knees last summer 2014. (Too many years of hard court tennis!!) After a few days of taking the TR, I could actually sleep without pain and am now able to do one mile hikes without resulting pain (I'm 75) and working my way back up to my 5 miles on the California Aqueduct each morning. Thanks Hammer!!! This actually works!!!! Cheers, Paul
Date published: 2015-03-05
Rated 5 out of 5 by from Helped me recover from surgery I have been unfortunate enough to have had abdominal surgery four times in the past 14 months. After my second surgery I started taking Tissue Rejuvenator regularly and as unscientific as this "study" is, I am convinced it helps me recover much faster. Yes, I am healthy, eat well and I'm very active all of which help recovery in general. But with Tissue Rejuvenator I was walking immediately after surgery, cycling a few days later, going for easy jogs within one week and running after two weeks. This is almost a full week faster than without. The ingredients seem to be focused on joints and I have not seen any studies that support taking Glucosamine but my personal experience has convinced me to keep taking this supplement even after surgery. As I ramp up my training load (running and cycling) during each of my recoveries I have been pain free.
Date published: 2016-05-20
Rated 5 out of 5 by from When a mistaking a mistake for a blessing!! Yesterday I took accidentally took 5 Tissue Rejuvenators at one time, having mistaken them for Premium Insurance Caps. Well, it could not have been a better day to make that "mistake" as kiting conditions were the choppiest I have been out in ever. Gusts up to about 30 mph in a direction against the wave direction which created thigh high peaky chop. Choppy conditions repeatedly pound and create shock waves through the legs. From novices to veterans, and for the young and not so young, the chop makes everyone's knees ache temporarily. But I was pleasantly surprised that I felt absolutely none of that infamous achiness!! And, my only reasoning is the extra Tissue Rejuvenator between an 10 mile run and my kite sesh!! As everyone else complained of knees feeling 10 years older, I was getting ready to jump on my bike for a quick ride around town! Thanks, Hammer!!
Date published: 2015-12-23
Rated 5 out of 5 by from Excellent product. We have used Tissue Rejuvenator for a long time. My wife and I are active Seniors, a biker and walker, and experience no movement disorders. TR perhaps played its most prominent role when together we walked in 2009 the Camino de Santiago ... 500 miles (800 KLM) in 33 days. I've ridden in the Alps, Pyrenees, Dolomites, and Rockies ... the Camino was the most difficult of all. Thanks, Hammer, for a great product.
Date published: 2014-09-02
Rated 3 out of 5 by from Not sure yet about this product. Feeling no difference after about 3 weeks. Going to stick with it and really hope that it works!
Date published: 2014-06-04
Rated 4 out of 5 by from Very Solid Training Product I've been using this TR for more than 6 months, Ill come at this from an angle most may not. If you do a lot of training for high level competition you need it plus other Hammer products. If you are just wanting to maintain or want to stay off Advil and other stuff it worth your wild! I put in about 7 hrs of weights a week, 15 hours of cardo in tennis, run, cycle and swim, so I take a bunch of stuff. TR has dropped my advil consumption by 75% so thats pretty huge! From my prespective its a must supplement for no matter your level of training.
Date published: 2016-05-19
Rated 1 out of 5 by from not effective for me not effective for me sending back taking 8 pills a day for 21/2 weeks now and find no results
Date published: 2014-10-01
Rated 5 out of 5 by from New knees I'd been having extreme knee pain for over a month that was continuously getting worse and making it so I had trouble getting in/out of a chair or just walking. I tried the Tissue Rejuvinators on a whim because I was desperate to get back to training. They worked within a week! I have no knee pain for the first time in almost a year!
Date published: 2016-05-23
Rated 5 out of 5 by from Fabulous Product Before I started using Tissue Rejuvenator, my seriously arthritic knees hurt almost all the time. Now I am virtually pain-free. My husband says the same thing about his shoulder. No other joint product we've tried has come close to keeping us out of the orthopedic surgeon's office. I've been a fan for almost 10 years now!
Date published: 2014-08-15
Rated 5 out of 5 by from tissue rejuvenator this is an amazing product It does really what the product is called i grew 2 extra fingers just kidding I have been using this product for 6 months and I noticed the immediate effect after hard work outs I had no more inflammation in my joints which i have been having for months prior me using it.I reccomend it strongly
Date published: 2014-12-04
Rated 5 out of 5 by from Love this product I am a 69 year old runner, biker, and swimmer. As I age I come up with more aches and pain in my joints. I have been taking two of these pills each day and by doing that have been able to not take arthritis meds that have been prescribed to me by physicians that I don't feel are as safe as this Hammer product.
Date published: 2016-12-18
Rated 5 out of 5 by from awesome I have been a high end rock climber for 23+ years. I had major shoulder surgery not even 3 weeks ago. I have been taking 3 tablets 2 x day since right before my surgery. I went in to PT today and was told that I am not only doing amazing well but my healing process is 2 weeks ahead of schedule :))) YES!!!
Date published: 2016-05-17
Rated 5 out of 5 by from Proven results Seven months of nagging shoulder pain. Tried numerous stretching techniques and months a strength training with no improvement. Before going to the doctor, I tried Tissue Rejuvenator. Started taking two capsules, twice per day, for two weeks. Pain was minimal and hard to reproduce after the first two weeks. After two more weeks of one capsule, twice per day, the pain has been gone for good. If any signs of pain start I will continue as needed, but so far I am one month pain free with hard use and training.
Date published: 2015-05-16
Rated 5 out of 5 by from Amazing for Aging Athletes! I've used Tissue Rejuvenator for over a decade and at age 59, it keeps me loose, limber and running day after day. If I forget to take it, I'm really stiff the morning after a run. If I overdo it, I take the injury dosage and it speeds up recovery. I feel 30!
Date published: 2016-07-19
Rated 5 out of 5 by from Truly works! I was having some knee pain after bicycling--nothing depilating, but annoying and especially noticeable going up or down stairs. I took the 2-caps 2x per day as recommended on the label for maintenance since I didn't consider the problem an "injury". However, I didn't notice any improvement so after about 3 weeks on the 2-caps 2x per day regimen, on a whim I went to 4-caps 2x per day and within a day or two, true noticeable relief! I'm very pleased with the results; I recommend this product highly.
Date published: 2014-10-03
Rated 5 out of 5 by from great purchase bought this 2 months ago after shoulder surgery, I don't like taking a lot of pain killers, this really helps with pain, when I experimented and did not take product, I did notice my discomfort level went up. So I am sticking with Tissue Rejuvenator.
Date published: 2016-11-29
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